G283-1827 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-[4-(methylsulfanyl)benzyl]acetamide

G283-1827 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-[4-(methylsulfanyl)benzyl]acetamide
G283-1827 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-[4-(methylsulfanyl)benzyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G283-1827
2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-[4-(methylsulfanyl)benzyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G283-1827

Molecular Formula

C22H25N3O3S2 (C22 H25 N3 O3 S2)

Compound Name

2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-[4-(methylsulfanyl)benzyl]acetamide

IUPAC name

2-{[5-(34-dimethylphenyl)-4-methyl-11-dioxo-1lambda62-thiazol-3-yl]amino}-N-{[4-(methylsulfanyl)phenyl]methyl}acetamide

SMILES

CC(C(NCC(NCc(cc1)ccc1SC)=O)=N1)=C(c2cc(C)c(C)cc2)S1(=O)=O

InChI

InChI=1S/C22H25N3O3S2/c1-14-5-8-18(11-15(14)2)21-16(3)22(25-30(21,27)28)24-13-20(26)23-12-17-6-9-19(29-4)10-7-17/h5-11H,12-13H2,1-4H3,(H,23,26)(H,24,25)

InChI Key

XANQUGASTCDPHK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14994601

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

443.59

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.302

Distribution Coefficient, logD

4.302

Water Solubility, LogSw

-4.23

Polar Surface Area

76.638

Acid Dissociation Constant (pKa)

12.00

Base Dissociation Constant (pKb)

-2.82

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.30

G283-1827 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G283-1827 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G283-1827?
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What is the minimum amount of G283-1827 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G283-1827
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G283-1827
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G283-1827 available by request