G288-0012 Screening compound: 2,3-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H,2H,3H,4H-pyrazino[1,2-a]indole-3-carboxamide

G288-0012 Screening compound: 2,3-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H,2H,3H,4H-pyrazino[1,2-a]indole-3-carboxamide
G288-0012 Screening compound: 2,3-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H,2H,3H,4H-pyrazino[1,2-a]indole-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G288-0012
2,3-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H,2H,3H,4H-pyrazino[1,2-a]indole-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G288-0012

Molecular Formula

C20H24N4O4 (C20 H24 N4 O4)

Compound Name

2,3-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H,2H,3H,4H-pyrazino[1,2-a]indole-3-carboxamide

IUPAC name

23-dimethyl-N-[2-(morpholin-4-yl)-2-oxoethyl]-1-oxo-1H2H3H4H-pyrazino[12-a]indole-3-carboxamide

SMILES

CC(Cn(c1c2)c3c2cccc3)(C(NCC(N2CCOCC2)=O)=O)N(C)C1=O

InChI

InChI=1S/C20H24N4O4/c1-20(19(27)21-12-17(25)23-7-9-28-10-8-23)13-24-15-6-4-3-5-14(15)11-16(24)18(26)22(20)2/h3-6,11H,7-10,12-13H2,1-2H3,(H,21,27)/t20-/m0/s1

InChI Key

PFFGPMOUOKHULD-FQEVSTJZSA-N

MDL Number (MFCD)

MFCD27213590

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

384.44

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

0.864

Distribution Coefficient, logD

0.864

Water Solubility, LogSw

-2.41

Polar Surface Area

65.350

Acid Dissociation Constant (pKa)

12.15

Base Dissociation Constant (pKb)

-0.62

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

45.00

G288-0012 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS MPO Library (28609 compounds)

Cyclic Ugi PPI Library (9586 compounds)

GPCR Targeted Library (31838 compounds)

PI3K-Targeted Library (17255 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

Targeted Diversity Library (40567 compounds)

Developmental Pathway (Hh/Wnt) Set (2238 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Digestive system
  • Female
  • Hemic and lymphatic
  • Skin
Mechanism of action:
  • PPI modulators
  • Receptor's ligands
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Mimetics
  • Mimetics
Targets:
  • GPCR
  • Kinases
  • Others

References: we are preparing a list of scientific research reports with G288-0012 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G288-0012?
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What is the minimum amount of G288-0012 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G288-0012
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G288-0012
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G288-0012 available by request