G345-0182 Screening compound: 4-[(6,7-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide

G345-0182 Screening compound: 4-[(6,7-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide
G345-0182 Screening compound: 4-[(6,7-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G345-0182
4-[(6,7-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G345-0182

Molecular Formula

C28H28N4O7 (C28 H28 N4 O7)

Compound Name

4-[(6,7-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide

IUPAC name

4-[(67-dimethoxy-1-{[(3-methoxyphenyl)carbamoyl]methyl}-24-dioxo-1234-tetrahydroquinazolin-3-yl)methyl]-N-methylbenzamide

SMILES

CNC(c1ccc(CN(C(c(cc(c(OC)c2)OC)c2N2CC(Nc3cc(OC)ccc3)=O)=O)C2=O)cc1)=O

InChI

InChI=1S/C28H28N4O7/c1-29-26(34)18-10-8-17(9-11-18)15-32-27(35)21-13-23(38-3)24(39-4)14-22(21)31(28(32)36)16-25(33)30-19-6-5-7-20(12-19)37-2/h5-14H,15-16H2,1-4H3,(H,29,34)(H,30,33)

InChI Key

HWZWLAZDCSGBMG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27136426

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

532.55

Hydrogen Bond Acceptors Count

11.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

11.00

Number of Nitrogen and Oxygen Atoms

11

Partition Coefficient, logP

3.084

Distribution Coefficient, logD

3.084

Water Solubility, LogSw

-3.41

Polar Surface Area

102.056

Acid Dissociation Constant (pKa)

11.87

Base Dissociation Constant (pKb)

0.78

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

21.40

G345-0182 in Drug Discovery

Included in Screening Libraries

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Peptidomimetic Library (37031 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
Therapeutical areas:
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Phosphatases

References: we are preparing a list of scientific research reports with G345-0182 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G345-0182?
Check Price and Availability of G345-0182, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G345-0182 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G345-0182
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G345-0182
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G345-0182 available by request