G345-0192 Screening compound: 4-{[6,7-dimethoxy-2,4-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide

G345-0192 Screening compound: 4-{[6,7-dimethoxy-2,4-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide
G345-0192 Screening compound: 4-{[6,7-dimethoxy-2,4-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G345-0192
4-{[6,7-dimethoxy-2,4-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G345-0192

Molecular Formula

C26H30N4O7 (C26 H30 N4 O7)

Compound Name

4-{[6,7-dimethoxy-2,4-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1,2,3,4-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide

IUPAC name

4-{[67-dimethoxy-24-dioxo-1-({[(oxolan-2-yl)methyl]carbamoyl}methyl)-1234-tetrahydroquinazolin-3-yl]methyl}-N-methylbenzamide

SMILES

CNC(c1ccc(CN(C(c(cc(c(OC)c2)OC)c2N2CC(NCC3OCCC3)=O)=O)C2=O)cc1)=O

InChI

InChI=1S/C26H30N4O7/c1-27-24(32)17-8-6-16(7-9-17)14-30-25(33)19-11-21(35-2)22(36-3)12-20(19)29(26(30)34)15-23(31)28-13-18-5-4-10-37-18/h6-9,11-12,18H,4-5,10,13-15H2,1-3H3,(H,27,32)(H,28,31)/t18-/m1/s1

InChI Key

MSHWVPNKLLZEKE-GOSISDBHSA-N

MDL Number (MFCD)

MFCD27136436

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

510.55

Hydrogen Bond Acceptors Count

11.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

11.00

Number of Nitrogen and Oxygen Atoms

11

Partition Coefficient, logP

1.051

Distribution Coefficient, logD

1.051

Water Solubility, LogSw

-2.46

Polar Surface Area

104.489

Acid Dissociation Constant (pKa)

13.73

Base Dissociation Constant (pKb)

-0.05

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

38.50

G345-0192 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G345-0192 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G345-0192?
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What is the minimum amount of G345-0192 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G345-0192
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G345-0192
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G345-0192 available by request