G364-1445 Screening compound: 2-[5-(4-chlorobenzyl)-1,1-dioxo-1lambda~6~,2,5-thiadiazolan-2-yl]-N~1~-(3,4-dimethoxyphenyl)acetamide

G364-1445 Screening compound: 2-[5-(4-chlorobenzyl)-1,1-dioxo-1lambda~6~,2,5-thiadiazolan-2-yl]-N~1~-(3,4-dimethoxyphenyl)acetamide
G364-1445 Screening compound: 2-[5-(4-chlorobenzyl)-1,1-dioxo-1lambda~6~,2,5-thiadiazolan-2-yl]-N~1~-(3,4-dimethoxyphenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G364-1445
2-[5-(4-chlorobenzyl)-1,1-dioxo-1lambda~6~,2,5-thiadiazolan-2-yl]-N~1~-(3,4-dimethoxyphenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G364-1445

Molecular Formula

C19H22ClN3O5S (C19 H22 ClN3 O5 S)

Compound Name

2-[5-(4-chlorobenzyl)-1,1-dioxo-1lambda~6~,2,5-thiadiazolan-2-yl]-N~1~-(3,4-dimethoxyphenyl)acetamide

IUPAC name

2-{5-[(4-chlorophenyl)methyl]-11-dioxo-1lambda625-thiadiazolidin-2-yl}-N-(34-dimethoxyphenyl)acetamide

SMILES

COc(ccc(NC(CN(CCN1Cc(cc2)ccc2Cl)S1(=O)=O)=O)c1)c1OC

InChI

InChI=1S/C19H22ClN3O5S/c1-27-17-8-7-16(11-18(17)28-2)21-19(24)13-23-10-9-22(29(23,25)26)12-14-3-5-15(20)6-4-14/h3-8,11H,9-10,12-13H2,1-2H3,(H,21,24)

InChI Key

ATSUMLYNCPHAJK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15003604

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

439.92

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.376

Distribution Coefficient, logD

2.376

Water Solubility, LogSw

-3.37

Polar Surface Area

75.155

Acid Dissociation Constant (pKa)

11.47

Base Dissociation Constant (pKb)

1.35

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.60

G364-1445 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Mechanism of action:
  • Epigenetic
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with G364-1445 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G364-1445?
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What is the minimum amount of G364-1445 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G364-1445
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G364-1445
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G364-1445 available by request