G373-1143 Screening compound: 2-[3-oxo-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide

G373-1143 Screening compound: 2-[3-oxo-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide
G373-1143 Screening compound: 2-[3-oxo-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G373-1143
2-[3-oxo-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G373-1143

Molecular Formula

C21H22N4O4 (C21 H22 N4 O4)

Compound Name

2-[3-oxo-6-(pyrrolidine-1-carbonyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide

IUPAC name

2-[3-oxo-6-(pyrrolidine-1-carbonyl)-34-dihydro-2H-14-benzoxazin-4-yl]-N-[(pyridin-2-yl)methyl]acetamide

SMILES

O=C(CN1c(cc(cc2)C(N3CCCC3)=O)c2OCC1=O)NCc1ncccc1

InChI

InChI=1S/C21H22N4O4/c26-19(23-12-16-5-1-2-8-22-16)13-25-17-11-15(21(28)24-9-3-4-10-24)6-7-18(17)29-14-20(25)27/h1-2,5-8,11H,3-4,9-10,12-14H2,(H,23,26)

InChI Key

XKRWBSQEIHEUFE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15005703

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

394.43

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

0.464

Distribution Coefficient, logD

0.463

Water Solubility, LogSw

-2.02

Polar Surface Area

75.097

Acid Dissociation Constant (pKa)

12.80

Base Dissociation Constant (pKb)

4.74

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G373-1143 in Drug Discovery

Included in Screening Libraries

CNS MPO Library (28609 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Others
  • Proteases
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G373-1143 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G373-1143?
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What is the minimum amount of G373-1143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G373-1143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G373-1143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G373-1143 available by request