G373-3777 Screening compound: ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate

G373-3777 Screening compound: ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate
G373-3777 Screening compound: ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate alternative view

Chemical Structure Depiction of ChemDiv screening compound G373-3777
ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G373-3777

Molecular Formula

C27H27FN6O3 (C27 H27 FN6 O3)

Compound Name

ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate

IUPAC name

ethyl 3-[(4-{[3-(3-fluorophenyl)-3H-imidazo[45-b]pyridin-2-yl]methyl}piperazine-1-carbonyl)amino]benzoate

SMILES

CCOC(c1cccc(NC(N2CCN(Cc3nc4cccnc4n3-c3cccc(F)c3)CC2)=O)c1)=O

InChI

InChI=1S/C27H27FN6O3/c1-2-37-26(35)19-6-3-8-21(16-19)30-27(36)33-14-12-32(13-15-33)18-24-31-23-10-5-11-29-25(23)34(24)22-9-4-7-20(28)17-22/h3-11,16-17H,2,12-15,18H2,1H3,(H,30,36)

InChI Key

CKDZOZJXZKICFL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27138123

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

502.55

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.853

Distribution Coefficient, logD

3.851

Water Solubility, LogSw

-3.80

Polar Surface Area

71.556

Acid Dissociation Constant (pKa)

13.45

Base Dissociation Constant (pKb)

4.82

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.90

G373-3777 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Chelators targeting matrix metalloproteinases library (8930 compounds)

MCL1 Targeted Library (12200 compounds)

PI3K-Targeted Library (17255 compounds)

Epigenetics Focused Set (26518 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Nervous system
  • Cardiovascular
Targets:
  • Proteases
  • Kinases
  • Ion Channels

References: we are preparing a list of scientific research reports with G373-3777 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G373-3777?
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What is the minimum amount of G373-3777 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G373-3777
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G373-3777
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G373-3777 available by request