G376-0228 Screening compound: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,7-trimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxamide

G376-0228 Screening compound: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,7-trimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxamide
G376-0228 Screening compound: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,7-trimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G376-0228
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,7-trimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G376-0228

Molecular Formula

C22H23N5O4 (C22 H23 N5 O4)

Compound Name

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-1,3,7-trimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxamide

IUPAC name

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-137-trimethyl-24-dioxo-1H2H3H4H-pyrido[23-d]pyrimidine-5-carboxamide

SMILES

Cc(cc1C(NCCc2c[nH]c(cc3)c2cc3OC)=O)nc(N(C)C(N2C)=O)c1C2=O

InChI

InChI=1S/C22H23N5O4/c1-12-9-16(18-19(25-12)26(2)22(30)27(3)21(18)29)20(28)23-8-7-13-11-24-17-6-5-14(31-4)10-15(13)17/h5-6,9-11,24H,7-8H2,1-4H3,(H,23,28)

InChI Key

NAUVELHGXLANST-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27138324

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

421.46

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

2.754

Distribution Coefficient, logD

2.754

Water Solubility, LogSw

-3.30

Polar Surface Area

82.716

Acid Dissociation Constant (pKa)

12.17

Base Dissociation Constant (pKb)

2.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.30

G376-0228 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

Anticancer Library (62698 compounds)

Chelators targeting matrix metalloproteinases library (8930 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Cardiovascular
Targets:
  • Proteases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with G376-0228 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G376-0228?
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What is the minimum amount of G376-0228 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G376-0228
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G376-0228
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G376-0228 available by request