G395-1484 Screening compound: 3-(6-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-N-(2,4-difluorophenyl)propanamide

G395-1484 Screening compound: 3-(6-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-N-(2,4-difluorophenyl)propanamide
G395-1484 Screening compound: 3-(6-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-N-(2,4-difluorophenyl)propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G395-1484
3-(6-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-N-(2,4-difluorophenyl)propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G395-1484

Molecular Formula

C22H18F2N6O3 (C22 H18 F2 N6 O3)

Compound Name

3-(6-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-N-(2,4-difluorophenyl)propanamide

IUPAC name

3-(6-{[(2H-13-benzodioxol-5-yl)methyl]amino}-[124]triazolo[43-b]pyridazin-3-yl)-N-(24-difluorophenyl)propanamide

SMILES

O=C(CCc1nnc(cc2)n1nc2NCc(cc1)cc2c1OCO2)Nc(ccc(F)c1)c1F

InChI

InChI=1S/C22H18F2N6O3/c23-14-2-3-16(15(24)10-14)26-22(31)8-7-21-28-27-20-6-5-19(29-30(20)21)25-11-13-1-4-17-18(9-13)33-12-32-17/h1-6,9-10H,7-8,11-12H2,(H,25,29)(H,26,31)

InChI Key

LMRGYSBBMFAQQA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15008114

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

452.42

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

2.264

Distribution Coefficient, logD

2.248

Water Solubility, LogSw

-3.00

Polar Surface Area

83.742

Acid Dissociation Constant (pKa)

8.84

Base Dissociation Constant (pKb)

1.64

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

G395-1484 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G395-1484 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G395-1484?
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What is the minimum amount of G395-1484 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G395-1484
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G395-1484
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G395-1484 available by request