G421-0161 Screening compound: 6-[(3-chlorophenyl)methyl]-N-(2,4-difluorophenyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

G421-0161 Screening compound: 6-[(3-chlorophenyl)methyl]-N-(2,4-difluorophenyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine
G421-0161 Screening compound: 6-[(3-chlorophenyl)methyl]-N-(2,4-difluorophenyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine alternative view

Chemical Structure Depiction of ChemDiv screening compound G421-0161
6-[(3-chlorophenyl)methyl]-N-(2,4-difluorophenyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G421-0161

Molecular Formula

C20H17ClF2N4 (C20 H17 ClF2 N4)

Compound Name

6-[(3-chlorophenyl)methyl]-N-(2,4-difluorophenyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

IUPAC name

6-[(3-chlorophenyl)methyl]-N-(24-difluorophenyl)-5H6H7H8H-pyrido[43-d]pyrimidin-2-amine

SMILES

Fc(cc1)cc(F)c1Nc1nc(CCN(Cc2cccc(Cl)c2)C2)c2cn1

InChI

InChI=1S/C20H17ClF2N4/c21-15-3-1-2-13(8-15)11-27-7-6-18-14(12-27)10-24-20(25-18)26-19-5-4-16(22)9-17(19)23/h1-5,8-10H,6-7,11-12H2,(H,24,25,26)

InChI Key

UVHHPERDSAHLQS-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15011953

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

386.83

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

4.551

Distribution Coefficient, logD

4.545

Water Solubility, LogSw

-4.56

Polar Surface Area

33.575

Acid Dissociation Constant (pKa)

14.63

Base Dissociation Constant (pKb)

5.53

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.00

G421-0161 in Drug Discovery

Included in Screening Libraries

CNS BBB Library (22607 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system

References: we are preparing a list of scientific research reports with G421-0161 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G421-0161?
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What is the minimum amount of G421-0161 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G421-0161
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G421-0161
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G421-0161 available by request