G421-0189 Screening compound: N-(2,4-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

G421-0189 Screening compound: N-(2,4-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine
G421-0189 Screening compound: N-(2,4-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine alternative view

Chemical Structure Depiction of ChemDiv screening compound G421-0189
N-(2,4-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G421-0189

Molecular Formula

C22H22F2N4O (C22 H22 F2 N4 O)

Compound Name

N-(2,4-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-amine

IUPAC name

N-(24-difluorophenyl)-6-[(4-ethoxyphenyl)methyl]-5H6H7H8H-pyrido[43-d]pyrimidin-2-amine

SMILES

CCOc1ccc(CN(CC2)Cc3c2nc(Nc(ccc(F)c2)c2F)nc3)cc1

InChI

InChI=1S/C22H22F2N4O/c1-2-29-18-6-3-15(4-7-18)13-28-10-9-20-16(14-28)12-25-22(26-20)27-21-8-5-17(23)11-19(21)24/h3-8,11-12H,2,9-10,13-14H2,1H3,(H,25,26,27)

InChI Key

FUEHEBSBHCQGSL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15011974

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

396.44

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.265

Distribution Coefficient, logD

4.257

Water Solubility, LogSw

-3.99

Polar Surface Area

40.699

Acid Dissociation Constant (pKa)

14.63

Base Dissociation Constant (pKb)

5.64

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.30

G421-0189 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer

References: we are preparing a list of scientific research reports with G421-0189 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G421-0189?
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What is the minimum amount of G421-0189 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G421-0189
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G421-0189
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G421-0189 available by request