G421-1244 Screening compound: 2-(4-{6-[(3,4,5-trimethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine

G421-1244 Screening compound: 2-(4-{6-[(3,4,5-trimethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine
G421-1244 Screening compound: 2-(4-{6-[(3,4,5-trimethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine alternative view

Chemical Structure Depiction of ChemDiv screening compound G421-1244
2-(4-{6-[(3,4,5-trimethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G421-1244

Molecular Formula

C25H31N7O3 (C25 H31 N7 O3)

Compound Name

2-(4-{6-[(3,4,5-trimethoxyphenyl)methyl]-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine

IUPAC name

2-(4-{6-[(345-trimethoxyphenyl)methyl]-5H6H7H8H-pyrido[43-d]pyrimidin-2-yl}piperazin-1-yl)pyrimidine

SMILES

COc1cc(CN(CC2)Cc3c2nc(N(CC2)CCN2c2ncccn2)nc3)cc(OC)c1OC

InChI

InChI=1S/C25H31N7O3/c1-33-21-13-18(14-22(34-2)23(21)35-3)16-30-8-5-20-19(17-30)15-28-25(29-20)32-11-9-31(10-12-32)24-26-6-4-7-27-24/h4,6-7,13-15H,5,8-12,16-17H2,1-3H3

InChI Key

KWLDSUMKXHXSHP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15012692

Chemical and Physical Properties

Saltdata

2HCl

Molecular Weight

477.57

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

10

Partition Coefficient, logP

2.548

Distribution Coefficient, logD

1.381

Water Solubility, LogSw

-2.48

Polar Surface Area

71.207

Acid Dissociation Constant (pKa)

20.66

Base Dissociation Constant (pKb)

8.54

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

44.00

G421-1244 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Included in 1.7M Stock Database

References: we are preparing a list of scientific research reports with G421-1244 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G421-1244?
Check Price and Availability of G421-1244, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G421-1244 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G421-1244
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G421-1244
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G421-1244 available by request