G427-1805 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide

G427-1805 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide
G427-1805 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G427-1805
3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G427-1805

Molecular Formula

C26H26F2N4O2 (C26 H26 F2 N4 O2)

Compound Name

3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide

IUPAC name

3-[6-ethoxy-1-(3-fluorophenyl)-34-dimethyl-1H-pyrazolo[34-b]pyridin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide

SMILES

CCOc1c(CCC(NCc(cc2)ccc2F)=O)c(C)c(c(C)nn2-c3cccc(F)c3)c2n1

InChI

InChI=1S/C26H26F2N4O2/c1-4-34-26-22(12-13-23(33)29-15-18-8-10-19(27)11-9-18)16(2)24-17(3)31-32(25(24)30-26)21-7-5-6-20(28)14-21/h5-11,14H,4,12-13,15H2,1-3H3,(H,29,33)

InChI Key

YTSLKIZTGBUYMV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27140866

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

464.52

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.017

Distribution Coefficient, logD

5.017

Water Solubility, LogSw

-4.93

Polar Surface Area

55.715

Acid Dissociation Constant (pKa)

12.32

Base Dissociation Constant (pKb)

0.63

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.90

G427-1805 in Drug Discovery

Included in Screening Libraries

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G427-1805 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G427-1805?
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What is the minimum amount of G427-1805 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G427-1805
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G427-1805
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G427-1805 available by request