G427-1810 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide

G427-1810 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide
G427-1810 Screening compound: 3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G427-1810
3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G427-1810

Molecular Formula

C29H30FN5O2 (C29 H30 FN5 O2)

Compound Name

3-[6-ethoxy-1-(3-fluorophenyl)-3,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide

IUPAC name

3-[6-ethoxy-1-(3-fluorophenyl)-34-dimethyl-1H-pyrazolo[34-b]pyridin-5-yl]-N-[2-(1H-indol-3-yl)ethyl]propanamide

SMILES

CCOc1c(CCC(NCCc2c[nH]c3c2cccc3)=O)c(C)c(c(C)nn2-c3cccc(F)c3)c2n1

InChI

InChI=1S/C29H30FN5O2/c1-4-37-29-23(12-13-26(36)31-15-14-20-17-32-25-11-6-5-10-24(20)25)18(2)27-19(3)34-35(28(27)33-29)22-9-7-8-21(30)16-22/h5-11,16-17,32H,4,12-15H2,1-3H3,(H,31,36)

InChI Key

GUAZYUYNNRVOAK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27140870

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

499.59

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

5.114

Distribution Coefficient, logD

5.114

Water Solubility, LogSw

-5.41

Polar Surface Area

65.427

Acid Dissociation Constant (pKa)

14.04

Base Dissociation Constant (pKb)

0.63

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.60

G427-1810 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • Epigenetic
Structure:
  • Mimetics
Therapeutical areas:
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system

References: we are preparing a list of scientific research reports with G427-1810 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G427-1810?
Check Price and Availability of G427-1810, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G427-1810 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G427-1810
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G427-1810
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G427-1810 available by request