G435-0146 Screening compound: 1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide

G435-0146 Screening compound: 1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide
G435-0146 Screening compound: 1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G435-0146
1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G435-0146

Molecular Formula

C23H22FN5OS (C23 H22 FN5 OS)

Compound Name

1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide

IUPAC name

1-[2-(4-fluorophenyl)pyrazolo[15-a]pyrazin-4-yl]-N-[(thiophen-2-yl)methyl]piperidine-4-carboxamide

SMILES

O=C(C(CC1)CCN1c(c1c2)nccn1nc2-c(cc1)ccc1F)NCc1cccs1

InChI

InChI=1S/C23H22FN5OS/c24-18-5-3-16(4-6-18)20-14-21-22(25-9-12-29(21)27-20)28-10-7-17(8-11-28)23(30)26-15-19-2-1-13-31-19/h1-6,9,12-14,17H,7-8,10-11,15H2,(H,26,30)

InChI Key

ZQNLUZXMEKIMBN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15014187

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

435.53

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.750

Distribution Coefficient, logD

3.748

Water Solubility, LogSw

-4.03

Polar Surface Area

48.706

Acid Dissociation Constant (pKa)

13.37

Base Dissociation Constant (pKb)

5.04

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.10

G435-0146 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with G435-0146 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G435-0146?
Check Price and Availability of G435-0146, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G435-0146 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G435-0146
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G435-0146
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G435-0146 available by request