G435-0657 Screening compound: 1-[2-(2,5-dimethylphenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide

G435-0657 Screening compound: 1-[2-(2,5-dimethylphenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide
G435-0657 Screening compound: 1-[2-(2,5-dimethylphenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G435-0657
1-[2-(2,5-dimethylphenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G435-0657

Molecular Formula

C26H26FN5O (C26 H26 FN5 O)

Compound Name

1-[2-(2,5-dimethylphenyl)pyrazolo[1,5-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide

IUPAC name

1-[2-(25-dimethylphenyl)pyrazolo[15-a]pyrazin-4-yl]-N-(4-fluorophenyl)piperidine-4-carboxamide

SMILES

Cc1cc(-c2nn(ccnc3N(CC4)CCC4C(Nc(cc4)ccc4F)=O)c3c2)c(C)cc1

InChI

InChI=1S/C26H26FN5O/c1-17-3-4-18(2)22(15-17)23-16-24-25(28-11-14-32(24)30-23)31-12-9-19(10-13-31)26(33)29-21-7-5-20(27)6-8-21/h3-8,11,14-16,19H,9-10,12-13H2,1-2H3,(H,29,33)

InChI Key

PNPLPPMXRHBKCK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27142179

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

443.52

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.688

Distribution Coefficient, logD

4.686

Water Solubility, LogSw

-4.32

Polar Surface Area

46.366

Acid Dissociation Constant (pKa)

10.28

Base Dissociation Constant (pKb)

5.04

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.90

G435-0657 in Drug Discovery

Included in Screening Libraries

CNS Targets (44014 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G435-0657 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G435-0657?
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What is the minimum amount of G435-0657 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G435-0657
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G435-0657
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G435-0657 available by request