G490-0551 Screening compound: 2-[2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]dec-1-en-8-yl]-N-(3,5-dimethoxyphenyl)acetamide

G490-0551 Screening compound: 2-[2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]dec-1-en-8-yl]-N-(3,5-dimethoxyphenyl)acetamide
G490-0551 Screening compound: 2-[2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]dec-1-en-8-yl]-N-(3,5-dimethoxyphenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G490-0551
2-[2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]dec-1-en-8-yl]-N-(3,5-dimethoxyphenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G490-0551

Molecular Formula

C23H25ClN4O4 (C23 H25 ClN4 O4)

Compound Name

2-[2-(4-chlorophenyl)-3-oxo-1,4,8-triazaspiro[4.5]dec-1-en-8-yl]-N-(3,5-dimethoxyphenyl)acetamide

IUPAC name

2-[2-(4-chlorophenyl)-3-oxo-148-triazaspiro[4.5]dec-1-en-8-yl]-N-(35-dimethoxyphenyl)acetamide

SMILES

COc1cc(NC(CN(CC2)CCC2(NC2=O)N=C2c(cc2)ccc2Cl)=O)cc(OC)c1

InChI

InChI=1S/C23H25ClN4O4/c1-31-18-11-17(12-19(13-18)32-2)25-20(29)14-28-9-7-23(8-10-28)26-21(22(30)27-23)15-3-5-16(24)6-4-15/h3-6,11-13H,7-10,14H2,1-2H3,(H,25,29)(H,27,30)

InChI Key

FLQNZNKAUHAHJC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15014619

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

456.93

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.493

Distribution Coefficient, logD

3.453

Water Solubility, LogSw

-4.05

Polar Surface Area

75.559

Acid Dissociation Constant (pKa)

9.36

Base Dissociation Constant (pKb)

6.33

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

34.80

G490-0551 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Neurotransmitter Transporter Inhibitors Library (11024 compounds)

Protein-Protein Interaction Library (218420 compounds)

Spiro Library (21655 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Nervous system
Targets:
  • GPCR
  • Ion Channels
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with G490-0551 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G490-0551?
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What is the minimum amount of G490-0551 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G490-0551
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G490-0551
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G490-0551 available by request