G516-1280 Screening compound: 8-[2-(4-chlorophenyl)quinazolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane

G516-1280 Screening compound: 8-[2-(4-chlorophenyl)quinazolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
G516-1280 Screening compound: 8-[2-(4-chlorophenyl)quinazolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane alternative view

Chemical Structure Depiction of ChemDiv screening compound G516-1280
8-[2-(4-chlorophenyl)quinazolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G516-1280

Molecular Formula

C21H20ClN3O2 (C21 H20 ClN3 O2)

Compound Name

8-[2-(4-chlorophenyl)quinazolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane

IUPAC name

8-[2-(4-chlorophenyl)quinazolin-4-yl]-14-dioxa-8-azaspiro[4.5]decane

SMILES

Clc(cc1)ccc1-c1nc2ccccc2c(N(CC2)CCC22OCCO2)n1

InChI

InChI=1S/C21H20ClN3O2/c22-16-7-5-15(6-8-16)19-23-18-4-2-1-3-17(18)20(24-19)25-11-9-21(10-12-25)26-13-14-27-21/h1-8H,9-14H2

InChI Key

CAFBIZQADFZWJW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15015121

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

381.86

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.289

Distribution Coefficient, logD

4.705

Water Solubility, LogSw

-6.25

Polar Surface Area

36.075

Acid Dissociation Constant (pKa)

22.62

Base Dissociation Constant (pKb)

7.85

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G516-1280 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS Targets (44014 compounds)

SmartTM Library (51161 compounds)

Voltage-Gated Ion Channel-Targeted Library (4740 compounds)

Akt-Targeted Library (14764 compounds)

New Agro Library (44492 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Nervous system
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Ion Channels
  • Kinases
Agro:
  • Agro

References: we are preparing a list of scientific research reports with G516-1280 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G516-1280?
Check Price and Availability of G516-1280, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G516-1280 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G516-1280
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G516-1280
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G516-1280 available by request