G546-0499 Screening compound: N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide

G546-0499 Screening compound: N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
G546-0499 Screening compound: N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G546-0499
N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G546-0499

Molecular Formula

C22H16ClN3O (C22 H16 ClN3 O)

Compound Name

N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide

IUPAC name

N-(4-chloro-2-methylphenyl)-2-(pyridin-2-yl)quinoline-4-carboxamide

SMILES

Cc(cc(cc1)Cl)c1NC(c1cc(-c2ncccc2)nc2ccccc12)=O

InChI

InChI=1S/C22H16ClN3O/c1-14-12-15(23)9-10-18(14)26-22(27)17-13-21(20-8-4-5-11-24-20)25-19-7-3-2-6-16(17)19/h2-13H,1H3,(H,26,27)

InChI Key

KPYGKOGTTWRSRF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27143808

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

373.84

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.355

Distribution Coefficient, logD

5.355

Water Solubility, LogSw

-5.89

Polar Surface Area

39.739

Acid Dissociation Constant (pKa)

10.79

Base Dissociation Constant (pKb)

3.15

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

4.50

G546-0499 in Drug Discovery

Included in Screening Libraries

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G546-0499 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G546-0499?
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What is the minimum amount of G546-0499 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G546-0499
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G546-0499
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G546-0499 available by request