G581-0297 Screening compound: 2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one

G581-0297 Screening compound: 2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one
G581-0297 Screening compound: 2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one alternative view

Chemical Structure Depiction of ChemDiv screening compound G581-0297
2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G581-0297

Molecular Formula

C23H27N5O3 (C23 H27 N5 O3)

Compound Name

2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidin-5-one

IUPAC name

2-(1-methyl-1H-indol-3-yl)-4-[4-(morpholin-4-yl)-4-oxobutyl]-4H5H6H7H-pyrazolo[15-a]pyrimidin-5-one

SMILES

Cn1c(cccc2)c2c(-c2nn(CCC(N3CCCC(N4CCOCC4)=O)=O)c3c2)c1

InChI

InChI=1S/C23H27N5O3/c1-25-16-18(17-5-2-3-6-20(17)25)19-15-21-27(23(30)8-10-28(21)24-19)9-4-7-22(29)26-11-13-31-14-12-26/h2-3,5-6,15-16H,4,7-14H2,1H3

InChI Key

KTDVNFCQDBRYOX-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15020595

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

421.5

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

1.329

Distribution Coefficient, logD

1.329

Water Solubility, LogSw

-2.03

Polar Surface Area

54.860

Acid Dissociation Constant (pKa)

22.67

Base Dissociation Constant (pKb)

2.11

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

43.50

G581-0297 in Drug Discovery

Included in Screening Libraries

Antiviral Library (67538 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • GPCR
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G581-0297 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G581-0297?
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What is the minimum amount of G581-0297 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G581-0297
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G581-0297
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G581-0297 available by request