G582-1277 Screening compound: 4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide

G582-1277 Screening compound: 4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide
G582-1277 Screening compound: 4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G582-1277
4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G582-1277

Molecular Formula

C22H16ClFN4O (C22 H16 ClFN4 O)

Compound Name

4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide

IUPAC name

4-[(4-chlorophenyl)amino]-N-(2-fluorophenyl)-N-methylquinazoline-2-carboxamide

SMILES

CN(C(c1nc2ccccc2c(Nc(cc2)ccc2Cl)n1)=O)c(cccc1)c1F

InChI

InChI=1S/C22H16ClFN4O/c1-28(19-9-5-3-7-17(19)24)22(29)21-26-18-8-4-2-6-16(18)20(27-21)25-15-12-10-14(23)11-13-15/h2-13H,1H3,(H,25,26,27)

InChI Key

BIODNRNKFVRAMJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15020659

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

406.85

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.383

Distribution Coefficient, logD

5.383

Water Solubility, LogSw

-6.01

Polar Surface Area

43.145

Acid Dissociation Constant (pKa)

16.10

Base Dissociation Constant (pKb)

-0.08

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

4.50

G582-1277 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Mechanism of action:
  • Epigenetic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G582-1277 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G582-1277?
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What is the minimum amount of G582-1277 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G582-1277
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G582-1277
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G582-1277 available by request