G637-1427 Screening compound: N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide

G637-1427 Screening compound: N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide
G637-1427 Screening compound: N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G637-1427
N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G637-1427

Molecular Formula

C28H40N4O4S (C28 H40 N4 O4 S)

Compound Name

N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(2,4,6-trimethylphenyl)ethenyl]-1,2-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide

IUPAC name

N-[(1-ethylpyrrolidin-2-yl)methyl]-1-({3-methyl-5-[(1E)-2-(246-trimethylphenyl)ethenyl]-12-oxazol-4-yl}sulfonyl)piperidine-4-carboxamide

SMILES

CCN1C(CNC(C(CC2)CCN2S(c2c(/C=C/c3c(C)cc(C)cc3C)onc2C)(=O)=O)=O)CCC1

InChI

InChI=1S/C28H40N4O4S/c1-6-31-13-7-8-24(31)18-29-28(33)23-11-14-32(15-12-23)37(34,35)27-22(5)30-36-26(27)10-9-25-20(3)16-19(2)17-21(25)4/h9-10,16-17,23-24H,6-8,11-15,18H2,1-5H3,(H,29,33)/t24-/m1/s1

InChI Key

RDMNHEGOVRLDRZ-XMMPIXPASA-N

MDL Number (MFCD)

MFCD15024596

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

528.72

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.796

Distribution Coefficient, logD

2.532

Water Solubility, LogSw

-3.66

Polar Surface Area

81.785

Acid Dissociation Constant (pKa)

13.09

Base Dissociation Constant (pKb)

8.64

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

57.10

G637-1427 in Drug Discovery

Included in Screening Libraries

MCL1 Targeted Library (12200 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with G637-1427 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G637-1427?
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What is the minimum amount of G637-1427 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G637-1427
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G637-1427
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G637-1427 available by request