G646-0864 Screening compound: 2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-1,4-dihydroquinolin-1-yl]-N-(2,4-dimethylphenyl)acetamide

G646-0864 Screening compound: 2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-1,4-dihydroquinolin-1-yl]-N-(2,4-dimethylphenyl)acetamide
G646-0864 Screening compound: 2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-1,4-dihydroquinolin-1-yl]-N-(2,4-dimethylphenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G646-0864
2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-1,4-dihydroquinolin-1-yl]-N-(2,4-dimethylphenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G646-0864

Molecular Formula

C26H22ClN3O4 (C26 H22 ClN3 O4)

Compound Name

2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-1,4-dihydroquinolin-1-yl]-N-(2,4-dimethylphenyl)acetamide

IUPAC name

2-[7-chloro-6-methoxy-4-oxo-3-(pyridine-4-carbonyl)-14-dihydroquinolin-1-yl]-N-(24-dimethylphenyl)acetamide

SMILES

Cc(cc1)cc(C)c1NC(CN(C=C(C(c1ccncc1)=O)C(c1c2)=O)c1cc(Cl)c2OC)=O

InChI

InChI=1S/C26H22ClN3O4/c1-15-4-5-21(16(2)10-15)29-24(31)14-30-13-19(25(32)17-6-8-28-9-7-17)26(33)18-11-23(34-3)20(27)12-22(18)30/h4-13H,14H2,1-3H3,(H,29,31)

InChI Key

IIQMFGFGVLRGAK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27149197

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

475.93

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.863

Distribution Coefficient, logD

3.863

Water Solubility, LogSw

-4.20

Polar Surface Area

68.540

Acid Dissociation Constant (pKa)

12.36

Base Dissociation Constant (pKb)

0.38

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

15.40

G646-0864 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Immune system
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G646-0864 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G646-0864?
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What is the minimum amount of G646-0864 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G646-0864
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G646-0864
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G646-0864 available by request