G721-0143 Screening compound: N-[(2-chlorophenyl)methyl]-2-{[1,3-dimethyl-2,4-dioxo-6-(propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

G721-0143 Screening compound: N-[(2-chlorophenyl)methyl]-2-{[1,3-dimethyl-2,4-dioxo-6-(propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide
G721-0143 Screening compound: N-[(2-chlorophenyl)methyl]-2-{[1,3-dimethyl-2,4-dioxo-6-(propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G721-0143
N-[(2-chlorophenyl)methyl]-2-{[1,3-dimethyl-2,4-dioxo-6-(propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G721-0143

Molecular Formula

C21H23ClN4O3S (C21 H23 ClN4 O3 S)

Compound Name

N-[(2-chlorophenyl)methyl]-2-{[1,3-dimethyl-2,4-dioxo-6-(propan-2-yl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

IUPAC name

N-[(2-chlorophenyl)methyl]-2-{[13-dimethyl-24-dioxo-6-(propan-2-yl)-1H2H3H4H-pyrido[23-d]pyrimidin-5-yl]sulfanyl}acetamide

SMILES

CC(C)c(c(SCC(NCc(cccc1)c1Cl)=O)c1C(N2C)=O)cnc1N(C)C2=O

InChI

InChI=1S/C21H23ClN4O3S/c1-12(2)14-10-24-19-17(20(28)26(4)21(29)25(19)3)18(14)30-11-16(27)23-9-13-7-5-6-8-15(13)22/h5-8,10,12H,9,11H2,1-4H3,(H,23,27)

InChI Key

UKYDQUMRGHXXCI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD08326322

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

446.96

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.826

Distribution Coefficient, logD

3.825

Water Solubility, LogSw

-4.32

Polar Surface Area

65.962

Acid Dissociation Constant (pKa)

13.25

Base Dissociation Constant (pKb)

4.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G721-0143 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

References: we are preparing a list of scientific research reports with G721-0143 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G721-0143?
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What is the minimum amount of G721-0143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G721-0143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G721-0143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G721-0143 available by request