G721-0514 Screening compound: N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

G721-0514 Screening compound: N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide
G721-0514 Screening compound: N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G721-0514
N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G721-0514

Molecular Formula

C18H20N4O5S (C18 H20 N4 O5 S)

Compound Name

N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-5-yl]sulfanyl}acetamide

IUPAC name

N-[(furan-2-yl)methyl]-2-{[6-(methoxymethyl)-13-dimethyl-24-dioxo-1H2H3H4H-pyrido[23-d]pyrimidin-5-yl]sulfanyl}acetamide

SMILES

CN(c1ncc(COC)c(SCC(NCc2ccco2)=O)c1C(N1C)=O)C1=O

InChI

InChI=1S/C18H20N4O5S/c1-21-16-14(17(24)22(2)18(21)25)15(11(7-20-16)9-26-3)28-10-13(23)19-8-12-5-4-6-27-12/h4-7H,8-10H2,1-3H3,(H,19,23)

InChI Key

CFKXWJXQYYHNCU-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD08326866

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

404.45

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

1.547

Distribution Coefficient, logD

1.547

Water Solubility, LogSw

-2.19

Polar Surface Area

82.134

Acid Dissociation Constant (pKa)

13.07

Base Dissociation Constant (pKb)

2.86

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G721-0514 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G721-0514 chemical compound. It will be published here after verification.

Frequently Asked Questions

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What is the minimum amount of G721-0514 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G721-0514
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G721-0514
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G721-0514 available by request