G768-0327 Screening compound: 7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

G768-0327 Screening compound: 7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
G768-0327 Screening compound: 7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one alternative view

Chemical Structure Depiction of ChemDiv screening compound G768-0327
7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G768-0327

Molecular Formula

C27H28ClN5O2S (C27 H28 ClN5 O2 S)

Compound Name

7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

IUPAC name

7-{[4-(4-tert-butylbenzoyl)piperazin-1-yl]methyl}-2-(2-chlorophenyl)-5H-[134]thiadiazolo[32-a]pyrimidin-5-one

SMILES

CC(C)(C)c(cc1)ccc1C(N1CCN(CC(N=C2SC(c(cccc3)c3Cl)=NN22)=CC2=O)CC1)=O

InChI

InChI=1S/C27H28ClN5O2S/c1-27(2,3)19-10-8-18(9-11-19)25(35)32-14-12-31(13-15-32)17-20-16-23(34)33-26(29-20)36-24(30-33)21-6-4-5-7-22(21)28/h4-11,16H,12-15,17H2,1-3H3

InChI Key

GTBWVEDLWDMOQT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27156569

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

522.07

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.518

Distribution Coefficient, logD

4.514

Water Solubility, LogSw

-4.55

Polar Surface Area

58.459

Acid Dissociation Constant (pKa)

28.24

Base Dissociation Constant (pKb)

5.33

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G768-0327 in Drug Discovery

Included in Screening Libraries

MCL1 Targeted Library (12200 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic

References: we are preparing a list of scientific research reports with G768-0327 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G768-0327?
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What is the minimum amount of G768-0327 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G768-0327
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G768-0327
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G768-0327 available by request