G817-0397 Screening compound: N-(4-methyl-1,3-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide

G817-0397 Screening compound: N-(4-methyl-1,3-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide
G817-0397 Screening compound: N-(4-methyl-1,3-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G817-0397
N-(4-methyl-1,3-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G817-0397

Molecular Formula

C18H18N4O2S (C18 H18 N4 O2 S)

Compound Name

N-(4-methyl-1,3-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide

IUPAC name

N-(4-methyl-13-thiazol-2-yl)-1-(morpholin-4-yl)isoquinoline-4-carboxamide

SMILES

Cc1csc(NC(c(c2ccccc22)cnc2N2CCOCC2)=O)n1

InChI

InChI=1S/C18H18N4O2S/c1-12-11-25-18(20-12)21-17(23)15-10-19-16(22-6-8-24-9-7-22)14-5-3-2-4-13(14)15/h2-5,10-11H,6-9H2,1H3,(H,20,21,23)

InChI Key

PLZPOZVVCPBLFA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15038775

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

354.43

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.229

Distribution Coefficient, logD

3.207

Water Solubility, LogSw

-3.30

Polar Surface Area

53.342

Acid Dissociation Constant (pKa)

9.29

Base Dissociation Constant (pKb)

6.00

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.80

G817-0397 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Anti-Aging Library (44940 compounds)

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

PI3K-Targeted Library (17255 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Akt-Targeted Library (14764 compounds)

Anti-HIV1 Library (19540 compounds)

Type II Kinase Inhibitors Library (6956 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Antiviral
  • Infections
  • Immune system
  • Digestive system
  • Hemic and lymphatic
  • Endocrine
Targets:
  • Kinases
  • GPCR
  • Kinases
  • Proteases
  • Kinases
  • Kinases
Mechanism of action:
  • Epigenetic
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G817-0397 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G817-0397?
Check Price and Availability of G817-0397, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of G817-0397 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G817-0397
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G817-0397
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G817-0397 available by request