G857-0278 Screening compound: 7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione

G857-0278 Screening compound: 7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione
G857-0278 Screening compound: 7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound G857-0278
7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G857-0278

Molecular Formula

C15H11FN2O3S2 (C15 H11 FN2 O3 S2)

Compound Name

7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-1lambda~6~,2,4-benzothiadiazine-1,1(4H)-dione

IUPAC name

7-fluoro-3-[(2-oxo-2-phenylethyl)sulfanyl]-4H-1lambda624-benzothiadiazine-11-dione

SMILES

O=C(CSC(Nc(cc1)c2cc1F)=NS2(=O)=O)c1ccccc1

InChI

InChI=1S/C15H11FN2O3S2/c16-11-6-7-12-14(8-11)23(20,21)18-15(17-12)22-9-13(19)10-4-2-1-3-5-10/h1-8H,9H2,(H,17,18)

InChI Key

XFGRFLUIFDTRHW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD07196697

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

350.39

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.433

Distribution Coefficient, logD

1.577

Water Solubility, LogSw

-2.98

Polar Surface Area

65.953

Acid Dissociation Constant (pKa)

6.61

Base Dissociation Constant (pKb)

1.13

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

6.70

G857-0278 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Immune system
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G857-0278 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G857-0278?
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What is the minimum amount of G857-0278 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G857-0278
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G857-0278
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G857-0278 available by request