G863-0248 Screening compound: 4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]methyl}benzamide

G863-0248 Screening compound: 4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]methyl}benzamide
G863-0248 Screening compound: 4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]methyl}benzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G863-0248
4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]methyl}benzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G863-0248

Molecular Formula

C21H21FN4O3S2 (C21 H21 FN4 O3 S2)

Compound Name

4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]methyl}benzamide

IUPAC name

4-(dimethylsulfamoyl)-N-{[6-(4-fluorophenyl)-2H3H-imidazo[21-b][13]thiazol-5-yl]methyl}benzamide

SMILES

CN(C)S(c(cc1)ccc1C(NCc1c(-c(cc2)ccc2F)nc2SCCn12)=O)(=O)=O

InChI

InChI=1S/C21H21FN4O3S2/c1-25(2)31(28,29)17-9-5-15(6-10-17)20(27)23-13-18-19(14-3-7-16(22)8-4-14)24-21-26(18)11-12-30-21/h3-10H,11-13H2,1-2H3,(H,23,27)

InChI Key

WACOALUYPVNPIQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09238999

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

460.55

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.923

Distribution Coefficient, logD

2.895

Water Solubility, LogSw

-3.56

Polar Surface Area

69.295

Acid Dissociation Constant (pKa)

10.59

Base Dissociation Constant (pKb)

6.22

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

23.80

G863-0248 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Indoleamine 2,3-dioxygenase 1 Focused Library (5816 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Cancer
  • Digestive system
  • Female
  • Hemic and lymphatic
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Others

References: we are preparing a list of scientific research reports with G863-0248 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G863-0248?
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What is the minimum amount of G863-0248 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G863-0248
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G863-0248
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G863-0248 available by request