G883-1618 Screening compound: 4-(6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]methyl}butanamide

G883-1618 Screening compound: 4-(6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]methyl}butanamide
G883-1618 Screening compound: 4-(6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]methyl}butanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G883-1618
4-(6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]methyl}butanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G883-1618

Molecular Formula

C30H31N3O4 (C30 H31 N3 O4)

Compound Name

4-(6-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]methyl}butanamide

IUPAC name

4-(6-methyl-3-oxo-34-dihydro-2H-14-benzoxazin-4-yl)-N-{[1-(3-methylbenzoyl)-23-dihydro-1H-indol-5-yl]methyl}butanamide

SMILES

Cc1cccc(C(N(CC2)c3c2cc(CNC(CCCN2c(cc(C)cc4)c4OCC2=O)=O)cc3)=O)c1

InChI

InChI=1S/C30H31N3O4/c1-20-5-3-6-24(15-20)30(36)33-14-12-23-17-22(9-10-25(23)33)18-31-28(34)7-4-13-32-26-16-21(2)8-11-27(26)37-19-29(32)35/h3,5-6,8-11,15-17H,4,7,12-14,18-19H2,1-2H3,(H,31,34)

InChI Key

JOUOYXXQBRXNRO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27165702

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

497.59

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.255

Distribution Coefficient, logD

3.255

Water Solubility, LogSw

-3.35

Polar Surface Area

64.197

Acid Dissociation Constant (pKa)

13.88

Base Dissociation Constant (pKb)

0.32

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.00

G883-1618 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with G883-1618 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G883-1618?
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What is the minimum amount of G883-1618 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G883-1618
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G883-1618
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G883-1618 available by request