G943-0473 Screening compound: N~1~-(10-cyclopropyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-2-{[(4-methylphenyl)sulfonyl]amino}propanamide

G943-0473 Screening compound: N~1~-(10-cyclopropyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-2-{[(4-methylphenyl)sulfonyl]amino}propanamide
G943-0473 Screening compound: N~1~-(10-cyclopropyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-2-{[(4-methylphenyl)sulfonyl]amino}propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G943-0473
N~1~-(10-cyclopropyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-2-{[(4-methylphenyl)sulfonyl]amino}propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G943-0473

Molecular Formula

C26H25N3O4S2 (C26 H25 N3 O4 S2)

Compound Name

N~1~-(10-cyclopropyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-2-{[(4-methylphenyl)sulfonyl]amino}propanamide

IUPAC name

N-{9-cyclopropyl-10-oxo-2-thia-9-azatricyclo[9.4.0.0^{38}]pentadeca-1(11)3571214-hexaen-5-yl}-2-(4-methylbenzenesulfonamido)propanamide

SMILES

CC(C(Nc(cc1)cc(Sc2c3cccc2)c1N(C1CC1)C3=O)=O)NS(c1ccc(C)cc1)(=O)=O

InChI

InChI=1S/C26H25N3O4S2/c1-16-7-12-20(13-8-16)35(32,33)28-17(2)25(30)27-18-9-14-22-24(15-18)34-23-6-4-3-5-21(23)26(31)29(22)19-10-11-19/h3-9,12-15,17,19,28H,10-11H2,1-2H3,(H,27,30)/t17-/m0/s1

InChI Key

AHHNREIFZNARKA-KRWDZBQOSA-N

MDL Number (MFCD)

MFCD15076612

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

507.63

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.994

Distribution Coefficient, logD

4.994

Water Solubility, LogSw

-4.56

Polar Surface Area

79.451

Acid Dissociation Constant (pKa)

10.86

Base Dissociation Constant (pKb)

-2.49

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

23.10

G943-0473 in Drug Discovery

Included in Screening Libraries

Antiviral Library (67538 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Protein-Protein Interaction Library (218420 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with G943-0473 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G943-0473?
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What is the minimum amount of G943-0473 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G943-0473
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G943-0473
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G943-0473 available by request