J021-2365 Screening compound: N-(3,5-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl}methyl)-1,2,4-oxadiazol-5-yl]propanamide

J021-2365 Screening compound: N-(3,5-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl}methyl)-1,2,4-oxadiazol-5-yl]propanamide
J021-2365 Screening compound: N-(3,5-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl}methyl)-1,2,4-oxadiazol-5-yl]propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound J021-2365
N-(3,5-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl}methyl)-1,2,4-oxadiazol-5-yl]propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

J021-2365

Molecular Formula

C22H18F2N4O2S2 (C22 H18 F2 N4 O2 S2)

Compound Name

N-(3,5-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl}methyl)-1,2,4-oxadiazol-5-yl]propanamide

IUPAC name

N-(35-difluorophenyl)-3-[3-({[4-(4-methylphenyl)-13-thiazol-2-yl]sulfanyl}methyl)-124-oxadiazol-5-yl]propanamide

SMILES

Cc(cc1)ccc1-c1csc(SCc2noc(CCC(Nc3cc(F)cc(F)c3)=O)n2)n1

InChI

InChI=1S/C22H18F2N4O2S2/c1-13-2-4-14(5-3-13)18-11-31-22(26-18)32-12-19-27-21(30-28-19)7-6-20(29)25-17-9-15(23)8-16(24)10-17/h2-5,8-11H,6-7,12H2,1H3,(H,25,29)

InChI Key

MAPSKANSQNWWAP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27218648

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

472.54

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

6.084

Distribution Coefficient, logD

6.066

Water Solubility, LogSw

-5.40

Polar Surface Area

64.545

Acid Dissociation Constant (pKa)

8.76

Base Dissociation Constant (pKb)

3.10

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

J021-2365 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

Histone Deacetylases (HDAC) Targeted Library (9760 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Endocrine
  • Immune system
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with J021-2365 chemical compound. It will be published here after verification.

Frequently Asked Questions

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What is the minimum amount of J021-2365 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for J021-2365
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for J021-2365
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of J021-2365 available by request