J024-0219 Screening compound: 11-(4-fluorophenyl)-N~10~,3,3-trimethyl-1-oxo-1,2,3,4,5,11-hexahydro-10H-dibenzo[b,e][1,4]diazepine-10-carboxamide

J024-0219 Screening compound: 11-(4-fluorophenyl)-N~10~,3,3-trimethyl-1-oxo-1,2,3,4,5,11-hexahydro-10H-dibenzo[b,e][1,4]diazepine-10-carboxamide
J024-0219 Screening compound: 11-(4-fluorophenyl)-N~10~,3,3-trimethyl-1-oxo-1,2,3,4,5,11-hexahydro-10H-dibenzo[b,e][1,4]diazepine-10-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound J024-0219
11-(4-fluorophenyl)-N~10~,3,3-trimethyl-1-oxo-1,2,3,4,5,11-hexahydro-10H-dibenzo[b,e][1,4]diazepine-10-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

J024-0219

Molecular Formula

C23H24FN3O2 (C23 H24 FN3 O2)

Compound Name

11-(4-fluorophenyl)-N~10~,3,3-trimethyl-1-oxo-1,2,3,4,5,11-hexahydro-10H-dibenzo[b,e][1,4]diazepine-10-carboxamide

IUPAC name

10-(4-fluorophenyl)-N1414-trimethyl-12-oxo-29-diazatricyclo[9.4.0.0^{38}]pentadeca-1(11)3(8)46-tetraene-9-carboxamide

SMILES

CC(C)(C1)CC(Nc(cccc2)c2N(C2c(cc3)ccc3F)C(NC)=O)=C2C1=O

InChI

InChI=1S/C23H24FN3O2/c1-23(2)12-17-20(19(28)13-23)21(14-8-10-15(24)11-9-14)27(22(29)25-3)18-7-5-4-6-16(18)26-17/h4-11,21,26H,12-13H2,1-3H3,(H,25,29)/t21-/m0/s1

InChI Key

PNQROIOCAOBPFZ-NRFANRHFSA-N

MDL Number (MFCD)

MFCD18912706

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

393.46

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.233

Distribution Coefficient, logD

4.211

Water Solubility, LogSw

-4.38

Polar Surface Area

49.730

Acid Dissociation Constant (pKa)

8.68

Base Dissociation Constant (pKb)

-0.91

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

30.40

J024-0219 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Protein-Protein Interaction Library (218420 compounds)

Targeted Diversity Library (40567 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with J024-0219 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound J024-0219?
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What is the minimum amount of J024-0219 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for J024-0219
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for J024-0219
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of J024-0219 available by request