J026-3815 Screening compound: methyl 1,7-dimethyl-2,4-dioxo-3-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxylate

J026-3815 Screening compound: methyl 1,7-dimethyl-2,4-dioxo-3-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxylate
J026-3815 Screening compound: methyl 1,7-dimethyl-2,4-dioxo-3-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxylate alternative view

Chemical Structure Depiction of ChemDiv screening compound J026-3815
methyl 1,7-dimethyl-2,4-dioxo-3-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxylate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

J026-3815

Molecular Formula

C22H24N4O5 (C22 H24 N4 O5)

Compound Name

methyl 1,7-dimethyl-2,4-dioxo-3-{[(2,4,6-trimethylphenyl)carbamoyl]methyl}-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-5-carboxylate

IUPAC name

methyl 17-dimethyl-24-dioxo-3-{[(246-trimethylphenyl)carbamoyl]methyl}-1H2H3H4H-pyrido[23-d]pyrimidine-5-carboxylate

SMILES

Cc(cc1C)cc(C)c1NC(CN(C(c1c(N2C)nc(C)cc1C(OC)=O)=O)C2=O)=O

InChI

InChI=1S/C22H24N4O5/c1-11-7-12(2)18(13(3)8-11)24-16(27)10-26-20(28)17-15(21(29)31-6)9-14(4)23-19(17)25(5)22(26)30/h7-9H,10H2,1-6H3,(H,24,27)

InChI Key

BDDNSAWYSLBZKL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09788500

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

424.46

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

2.748

Distribution Coefficient, logD

2.748

Water Solubility, LogSw

-2.87

Polar Surface Area

83.937

Acid Dissociation Constant (pKa)

12.56

Base Dissociation Constant (pKb)

2.27

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.80

J026-3815 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

Chelators targeting matrix metalloproteinases library (8930 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Cardiovascular
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Proteases
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with J026-3815 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound J026-3815?
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What is the minimum amount of J026-3815 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for J026-3815
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for J026-3815
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of J026-3815 available by request