J026-4222 Screening compound: 1,7-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione

J026-4222 Screening compound: 1,7-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione
J026-4222 Screening compound: 1,7-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound J026-4222
1,7-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

J026-4222

Molecular Formula

C23H26N4O3 (C23 H26 N4 O3)

Compound Name

1,7-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione

IUPAC name

17-dimethyl-3-[(2-methylphenyl)methyl]-5-(piperidine-1-carbonyl)-1H2H3H4H-pyrido[23-d]pyrimidine-24-dione

SMILES

Cc1c(CN(C(c2c(N3C)nc(C)cc2C(N2CCCCC2)=O)=O)C3=O)cccc1

InChI

InChI=1S/C23H26N4O3/c1-15-9-5-6-10-17(15)14-27-22(29)19-18(21(28)26-11-7-4-8-12-26)13-16(2)24-20(19)25(3)23(27)30/h5-6,9-10,13H,4,7-8,11-12,14H2,1-3H3

InChI Key

ZQKAZUNCCMFMEY-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09788534

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

406.48

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.706

Distribution Coefficient, logD

3.706

Water Solubility, LogSw

-3.87

Polar Surface Area

57.658

Acid Dissociation Constant (pKa)

26.51

Base Dissociation Constant (pKb)

3.24

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

39.10

J026-4222 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Hsp90-Targeted Library (11355 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with J026-4222 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound J026-4222?
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What is the minimum amount of J026-4222 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for J026-4222
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for J026-4222
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of J026-4222 available by request