K273-0157 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

K273-0157 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one
K273-0157 Screening compound: 17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one alternative view

Chemical Structure Depiction of ChemDiv screening compound K273-0157
17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K273-0157

Molecular Formula

C28H31NO3 (C28 H31 NO3)

Compound Name

17-[(Z,2E)-1-hydroxy-3-(4-methylphenyl)-2-propenylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

IUPAC name

(17Z)-17-[(2E)-1-hydroxy-3-(4-methylphenyl)prop-2-en-1-ylidene]-15-propyl-2-oxa-15-azatetracyclo[7.5.3.0^{110}.0^{38}]heptadeca-357-trien-16-one

SMILES

CCCN(C(CCCC1)(C1C1/C2=C(\C=C\c3ccc(C)cc3)/O)Oc3c1cccc3)C2=O

InChI

InChI=1S/C28H31NO3/c1-3-18-29-27(31)26(23(30)16-15-20-13-11-19(2)12-14-20)25-21-8-4-5-10-24(21)32-28(29)17-7-6-9-22(25)28/h4-5,8,10-16,22,25,30H,3,6-7,9,17-18H2,1-2H3

InChI Key

RJSILIMLFOXVLP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15086368

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

429.56

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

6.166

Distribution Coefficient, logD

6.166

Water Solubility, LogSw

-5.39

Polar Surface Area

39.002

Acid Dissociation Constant (pKa)

11.80

Base Dissociation Constant (pKb)

1.14

Number of Chiral Centers

3.00

Percent sp3 carbon bonding

39.30

K273-0157 in Drug Discovery

Included in Screening Libraries

Anti-infective Library (19449 compounds)

DGK Inhibitors Library (10558 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Immune system
  • animal
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with K273-0157 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K273-0157?
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What is the minimum amount of K273-0157 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K273-0157
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K273-0157
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K273-0157 available by request