K273-0174 Screening compound: 17-[(Z,2E)-3-(4-chlorophenyl)-1-hydroxy-2-propenylidene]-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

K273-0174 Screening compound: 17-[(Z,2E)-3-(4-chlorophenyl)-1-hydroxy-2-propenylidene]-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one
K273-0174 Screening compound: 17-[(Z,2E)-3-(4-chlorophenyl)-1-hydroxy-2-propenylidene]-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one alternative view

Chemical Structure Depiction of ChemDiv screening compound K273-0174
17-[(Z,2E)-3-(4-chlorophenyl)-1-hydroxy-2-propenylidene]-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K273-0174

Molecular Formula

C24H22ClNO3 (C24 H22 ClNO3)

Compound Name

17-[(Z,2E)-3-(4-chlorophenyl)-1-hydroxy-2-propenylidene]-2-oxa-15-azatetracyclo[7.5.3.0~1,10~.0~3,8~]heptadeca-3,5,7-trien-16-one

IUPAC name

(17Z)-17-[(2E)-3-(4-chlorophenyl)-1-hydroxyprop-2-en-1-ylidene]-2-oxa-15-azatetracyclo[7.5.3.0^{110}.0^{38}]heptadeca-357-trien-16-one

SMILES

O/C(/C=C/c(cc1)ccc1Cl)=C(/C(C1CCCC2)c(cccc3)c3OC12N1)\C1=O

InChI

InChI=1S/C24H22ClNO3/c25-16-11-8-15(9-12-16)10-13-19(27)22-21-17-5-1-2-7-20(17)29-24(26-23(22)28)14-4-3-6-18(21)24/h1-2,5,7-13,18,21,27H,3-4,6,14H2,(H,26,28)

InChI Key

JVJWLARJLKCNHI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD05030023

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

407.9

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.088

Distribution Coefficient, logD

5.088

Water Solubility, LogSw

-5.40

Polar Surface Area

50.107

Acid Dissociation Constant (pKa)

10.71

Base Dissociation Constant (pKb)

-1.22

Number of Chiral Centers

3.00

Percent sp3 carbon bonding

29.20

K273-0174 in Drug Discovery

Included in Screening Libraries

Anti-infective Library (19449 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

DGK Inhibitors Library (10558 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Epitranscriptome Focused Small Molecule Library (20952 compounds)

New Agro Library (44492 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Immune system
  • animal
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
  • Nervous system
  • Hemic and lymphatic
  • Congenital
  • Metabolic
Targets:
  • Kinases
Mechanism of action:
  • Epigenetic
Agro:
  • Agro

References: we are preparing a list of scientific research reports with K273-0174 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K273-0174?
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What is the minimum amount of K273-0174 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K273-0174
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K273-0174
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K273-0174 available by request