K273-0185 Screening compound: 9,10-dimethyl-12-[5-(1-naphthylamino)-1,3,4-thiadiazol-2-yl]-8-oxa-10-azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-trien-11-one
Chemical Structure Depiction of ChemDiv screening compound K273-0185
9,10-dimethyl-12-[5-(1-naphthylamino)-1,3,4-thiadiazol-2-yl]-8-oxa-10-azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-trien-11-one
Available from 1 mg
Formats:
- Glass Vials (4ml Glass Vials VWR #97047-678)
- 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)
Shiptime: 1 week worldwide delivery in most cases
Compound Identifiers
ChemDiv Compound ID
K273-0185
Molecular Formula
C25H22N4O2S (C25 H22 N4 O2 S)
Compound Name
9,10-dimethyl-12-[5-(1-naphthylamino)-1,3,4-thiadiazol-2-yl]-8-oxa-10-azatricyclo[7.3.1.0~2,7~]trideca-2,4,6-trien-11-one
IUPAC name
n/a
SMILES
CC(CC1C2c3nnc(Nc4cccc5ccccc45)s3)(N(C)C2=O)Oc2c1cccc2
InChI Key
MDL Number (MFCD)
Chemical and Physical Properties
Saltdata
n/a
Molecular Weight
442.54
Hydrogen Bond Acceptors Count
5.00
Hydrogen Bond Donors Count
1.00
Rotatable Bond Count
3.00
Number of Nitrogen and Oxygen Atoms
6
Partition Coefficient, logP
4.876
Distribution Coefficient, logD
4.876
Water Solubility, LogSw
-5.33
Polar Surface Area
52.977
Acid Dissociation Constant (pKa)
16.99
Base Dissociation Constant (pKb)
-0.90
Number of Chiral Centers
3.00
Percent sp3 carbon bonding
24.00
K273-0185 in Drug Discovery
Included in Screening Libraries
DGK Inhibitors Library (10558 compounds)
Macl-GPIb alpha Interaction Library (22969 compounds)
Protein-Protein Interaction Library (218420 compounds)
Spiro Library (21655 compounds)
Included in 1.7M Stock Database
- Cancer
- Digestive system
- Hemic and lymphatic
- Skin
- Metabolic
- Immune system
- Hemic and lymphatic
- Cardiovascular
- Kinases
- PPI modulators
- PPI modulators
- Cyclic compounds
References: we are preparing a list of scientific research reports with K273-0185 chemical compound. It will be published here after verification.
Frequently Asked Questions
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Available from 1 mg in Glass Vials or 96-tube racks.
ChemDiv sends parcels with Express services (UPS, WC).
- 1–2 days for small orders
- 2–4 weeks for large selections
- 0.5–50 mg of dry powder sample in single glass vials, custom vials
- DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)