K277-0052 Screening compound: 3-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one

K277-0052 Screening compound: 3-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one
K277-0052 Screening compound: 3-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound K277-0052
3-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K277-0052

Molecular Formula

C20H15NO3S (C20 H15 NO3 S)

Compound Name

3-[4-(3,4-dimethylphenyl)-1,3-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one

IUPAC name

3-[4-(34-dimethylphenyl)-13-thiazol-2-yl]-7-hydroxy-2H-chromen-2-one

SMILES

Cc(cc1)c(C)cc1-c1csc(C2=Cc(ccc(O)c3)c3OC2=O)n1

InChI

InChI=1S/C20H15NO3S/c1-11-3-4-13(7-12(11)2)17-10-25-19(21-17)16-8-14-5-6-15(22)9-18(14)24-20(16)23/h3-10,22H,1-2H3

InChI Key

GNGHAEFOFQWKFW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15086442

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

349.41

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.215

Distribution Coefficient, logD

5.143

Water Solubility, LogSw

-4.98

Polar Surface Area

48.240

Acid Dissociation Constant (pKa)

8.14

Base Dissociation Constant (pKb)

-3.78

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

10.00

K277-0052 in Drug Discovery

Included in Screening Libraries

Hsp90-Targeted Library (11355 compounds)

Carbonic Anhydrase II Library (4939 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system

References: we are preparing a list of scientific research reports with K277-0052 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K277-0052?
Check Price and Availability of K277-0052, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of K277-0052 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K277-0052
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K277-0052
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K277-0052 available by request