K305-0363 Screening compound: 3-(4-fluorophenyl)-N,N,5-trimethyl-2,4-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-6-carboxamide

K305-0363 Screening compound: 3-(4-fluorophenyl)-N,N,5-trimethyl-2,4-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-6-carboxamide
K305-0363 Screening compound: 3-(4-fluorophenyl)-N,N,5-trimethyl-2,4-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-6-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound K305-0363
3-(4-fluorophenyl)-N,N,5-trimethyl-2,4-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-6-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K305-0363

Molecular Formula

C25H20F4N4O4S (C25 H20 F4 N4 O4 S)

Compound Name

3-(4-fluorophenyl)-N,N,5-trimethyl-2,4-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-6-carboxamide

IUPAC name

3-(4-fluorophenyl)-NN5-trimethyl-24-dioxo-1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H2H3H4H-thieno[23-d]pyrimidine-6-carboxamide

SMILES

Cc1c(C(N(C)C)=O)sc(N(CC(Nc2c(C(F)(F)F)cccc2)=O)C(N2c(cc3)ccc3F)=O)c1C2=O

InChI

InChI=1S/C25H20F4N4O4S/c1-13-19-21(35)33(15-10-8-14(26)9-11-15)24(37)32(23(19)38-20(13)22(36)31(2)3)12-18(34)30-17-7-5-4-6-16(17)25(27,28)29/h4-11H,12H2,1-3H3,(H,30,34)

InChI Key

OLLJIEJOKVCBLM-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15092934

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

548.52

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.098

Distribution Coefficient, logD

3.098

Water Solubility, LogSw

-3.46

Polar Surface Area

69.559

Acid Dissociation Constant (pKa)

12.78

Base Dissociation Constant (pKb)

0.34

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.00

K305-0363 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

MCL1 Targeted Library (12200 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic

References: we are preparing a list of scientific research reports with K305-0363 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K305-0363?
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What is the minimum amount of K305-0363 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K305-0363
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K305-0363
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K305-0363 available by request