K410-0327 Screening compound: 2-chloro-N~1~-[2-(3-chlorophenyl)-5,5-dioxo-2,4,5,6-tetrahydro-5lambda~6~-thieno[3,4-c]pyrazol-3-yl]-6-fluorobenzamide

K410-0327 Screening compound: 2-chloro-N~1~-[2-(3-chlorophenyl)-5,5-dioxo-2,4,5,6-tetrahydro-5lambda~6~-thieno[3,4-c]pyrazol-3-yl]-6-fluorobenzamide
K410-0327 Screening compound: 2-chloro-N~1~-[2-(3-chlorophenyl)-5,5-dioxo-2,4,5,6-tetrahydro-5lambda~6~-thieno[3,4-c]pyrazol-3-yl]-6-fluorobenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound K410-0327
2-chloro-N~1~-[2-(3-chlorophenyl)-5,5-dioxo-2,4,5,6-tetrahydro-5lambda~6~-thieno[3,4-c]pyrazol-3-yl]-6-fluorobenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K410-0327

Molecular Formula

C18H12Cl2FN3O3S (C18 H12 Cl2 FN3 O3 S)

Compound Name

2-chloro-N~1~-[2-(3-chlorophenyl)-5,5-dioxo-2,4,5,6-tetrahydro-5lambda~6~-thieno[3,4-c]pyrazol-3-yl]-6-fluorobenzamide

IUPAC name

2-chloro-N-[2-(3-chlorophenyl)-55-dioxo-2H4H6H-5lambda6-thieno[34-c]pyrazol-3-yl]-6-fluorobenzamide

SMILES

O=C(c(c(F)ccc1)c1Cl)Nc1c(CS(C2)(=O)=O)c2nn1-c1cc(Cl)ccc1

InChI

InChI=1S/C18H12Cl2FN3O3S/c19-10-3-1-4-11(7-10)24-17(12-8-28(26,27)9-15(12)23-24)22-18(25)16-13(20)5-2-6-14(16)21/h1-7H,8-9H2,(H,22,25)

InChI Key

PDMFKMQWHHHYTA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD04452145

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

440.28

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.215

Distribution Coefficient, logD

2.510

Water Solubility, LogSw

-3.95

Polar Surface Area

66.701

Acid Dissociation Constant (pKa)

6.79

Base Dissociation Constant (pKb)

-4.23

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

11.10

K410-0327 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Type II Kinase Inhibitors Library (6956 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Digestive system
  • Hemic and lymphatic
  • Endocrine
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with K410-0327 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K410-0327?
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What is the minimum amount of K410-0327 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K410-0327
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K410-0327
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K410-0327 available by request