K832-4194 Screening compound: 4-(5-bromo-2-fluorophenyl)-2-(4-chlorophenyl)-1,4-dihydropyrimido[1,2-a][1,3]benzimidazole

K832-4194 Screening compound: 4-(5-bromo-2-fluorophenyl)-2-(4-chlorophenyl)-1,4-dihydropyrimido[1,2-a][1,3]benzimidazole
K832-4194 Screening compound: 4-(5-bromo-2-fluorophenyl)-2-(4-chlorophenyl)-1,4-dihydropyrimido[1,2-a][1,3]benzimidazole alternative view

Chemical Structure Depiction of ChemDiv screening compound K832-4194
4-(5-bromo-2-fluorophenyl)-2-(4-chlorophenyl)-1,4-dihydropyrimido[1,2-a][1,3]benzimidazole

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K832-4194

Molecular Formula

C22H14BrClFN3 (C22 H14 BrClFN3)

Compound Name

4-(5-bromo-2-fluorophenyl)-2-(4-chlorophenyl)-1,4-dihydropyrimido[1,2-a][1,3]benzimidazole

IUPAC name

13-(5-bromo-2-fluorophenyl)-11-(4-chlorophenyl)-1810-triazatricyclo[7.4.0.0^{27}]trideca-2(7)35811-pentaene

SMILES

Fc(cc1)c(C(C=C(c(cc2)ccc2Cl)N2)n3c2nc2c3cccc2)cc1Br

InChI

InChI=1S/C22H14BrClFN3/c23-14-7-10-17(25)16(11-14)21-12-19(13-5-8-15(24)9-6-13)27-22-26-18-3-1-2-4-20(18)28(21)22/h1-12,21H,(H,26,27)/t21-/m0/s1

InChI Key

HUAPHDGNZVXPQN-NRFANRHFSA-N

MDL Number (MFCD)

MFCD15110191

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

454.73

Hydrogen Bond Acceptors Count

1.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

2.00

Number of Nitrogen and Oxygen Atoms

3

Partition Coefficient, logP

7.109

Distribution Coefficient, logD

7.109

Water Solubility, LogSw

-6.95

Polar Surface Area

24.644

Acid Dissociation Constant (pKa)

10.77

Base Dissociation Constant (pKb)

0.71

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

4.50

K832-4194 in Drug Discovery

Included in Screening Libraries

DGK Inhibitors Library (10558 compounds)

KRAS-Targeted Library (16000 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with K832-4194 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K832-4194?
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What is the minimum amount of K832-4194 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K832-4194
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K832-4194
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K832-4194 available by request