K832-4265 Screening compound: 4-{4-[5-chloro-2-(difluoromethoxy)phenyl]-1,4-dihydropyrimido[1,2-a][1,3]benzimidazol-2-yl}phenyl methyl ether

K832-4265 Screening compound: 4-{4-[5-chloro-2-(difluoromethoxy)phenyl]-1,4-dihydropyrimido[1,2-a][1,3]benzimidazol-2-yl}phenyl methyl ether
K832-4265 Screening compound: 4-{4-[5-chloro-2-(difluoromethoxy)phenyl]-1,4-dihydropyrimido[1,2-a][1,3]benzimidazol-2-yl}phenyl methyl ether alternative view

Chemical Structure Depiction of ChemDiv screening compound K832-4265
4-{4-[5-chloro-2-(difluoromethoxy)phenyl]-1,4-dihydropyrimido[1,2-a][1,3]benzimidazol-2-yl}phenyl methyl ether

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

K832-4265

Molecular Formula

C24H18ClF2N3O2 (C24 H18 ClF2 N3 O2)

Compound Name

4-{4-[5-chloro-2-(difluoromethoxy)phenyl]-1,4-dihydropyrimido[1,2-a][1,3]benzimidazol-2-yl}phenyl methyl ether

IUPAC name

13-[5-chloro-2-(difluoromethoxy)phenyl]-11-(4-methoxyphenyl)-1810-triazatricyclo[7.4.0.0^{27}]trideca-2(7)35811-pentaene

SMILES

COc(cc1)ccc1C(N1)=CC(c(cc(cc2)Cl)c2OC(F)F)n2c1nc1c2cccc1

InChI

InChI=1S/C24H18ClF2N3O2/c1-31-16-9-6-14(7-10-16)19-13-21(17-12-15(25)8-11-22(17)32-23(26)27)30-20-5-3-2-4-18(20)28-24(30)29-19/h2-13,21,23H,1H3,(H,28,29)/t21-/m0/s1

InChI Key

MTAIJBZKZUTXRI-NRFANRHFSA-N

MDL Number (MFCD)

MFCD15110220

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

453.88

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

6.311

Distribution Coefficient, logD

6.311

Water Solubility, LogSw

-6.36

Polar Surface Area

38.880

Acid Dissociation Constant (pKa)

11.85

Base Dissociation Constant (pKb)

1.13

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

12.50

K832-4265 in Drug Discovery

Included in Screening Libraries

DGK Inhibitors Library (10558 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with K832-4265 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound K832-4265?
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What is the minimum amount of K832-4265 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for K832-4265
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for K832-4265
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of K832-4265 available by request