L120-1158 Screening compound: N-(3,5-dimethylphenyl)-6,6-dimethyl-2-(4-methylphenyl)-3,8-dioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide

L120-1158 Screening compound: N-(3,5-dimethylphenyl)-6,6-dimethyl-2-(4-methylphenyl)-3,8-dioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide
L120-1158 Screening compound: N-(3,5-dimethylphenyl)-6,6-dimethyl-2-(4-methylphenyl)-3,8-dioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L120-1158
N-(3,5-dimethylphenyl)-6,6-dimethyl-2-(4-methylphenyl)-3,8-dioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L120-1158

Molecular Formula

C27H28N2O3 (C27 H28 N2 O3)

Compound Name

N-(3,5-dimethylphenyl)-6,6-dimethyl-2-(4-methylphenyl)-3,8-dioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carboxamide

IUPAC name

N-(35-dimethylphenyl)-66-dimethyl-2-(4-methylphenyl)-38-dioxo-235678-hexahydroisoquinoline-4-carboxamide

SMILES

CC(C)(CC(C1=CN2c3ccc(C)cc3)=C(C(Nc3cc(C)cc(C)c3)=O)C2=O)CC1=O

InChI

InChI=1S/C27H28N2O3/c1-16-6-8-20(9-7-16)29-15-22-21(13-27(4,5)14-23(22)30)24(26(29)32)25(31)28-19-11-17(2)10-18(3)12-19/h6-12,15H,13-14H2,1-5H3,(H,28,31)

InChI Key

GEPWRZANFGPRNT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27233831

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

428.53

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.374

Distribution Coefficient, logD

4.367

Water Solubility, LogSw

-4.41

Polar Surface Area

52.286

Acid Dissociation Constant (pKa)

9.22

Base Dissociation Constant (pKb)

-2.36

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

29.60

L120-1158 in Drug Discovery

Included in Screening Libraries

C-Met Library (15277 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Kinases
  • Phosphatases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L120-1158 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L120-1158?
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What is the minimum amount of L120-1158 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L120-1158
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L120-1158
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L120-1158 available by request