L154-0273 Screening compound: N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide

L154-0273 Screening compound: N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide
L154-0273 Screening compound: N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L154-0273
N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L154-0273

Molecular Formula

C18H20ClFN4O (C18 H20 ClFN4 O)

Compound Name

N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide

IUPAC name

N-[(2-chloro-4-fluorophenyl)methyl]-1-(4-methylpyrimidin-2-yl)piperidine-3-carboxamide

SMILES

Cc1ccnc(N(CCC2)CC2C(NCc(ccc(F)c2)c2Cl)=O)n1

InChI

InChI=1S/C18H20ClFN4O/c1-12-6-7-21-18(23-12)24-8-2-3-14(11-24)17(25)22-10-13-4-5-15(20)9-16(13)19/h4-7,9,14H,2-3,8,10-11H2,1H3,(H,22,25)/t14-/m0/s1

InChI Key

CMTPZJBXFLVYSF-AWEZNQCLSA-N

MDL Number (MFCD)

MFCD27234899

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

362.83

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.182

Distribution Coefficient, logD

3.182

Water Solubility, LogSw

-3.42

Polar Surface Area

45.774

Acid Dissociation Constant (pKa)

12.07

Base Dissociation Constant (pKb)

3.59

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

38.90

L154-0273 in Drug Discovery

Included in Screening Libraries

Anti-Inflammatory Library (24602 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with L154-0273 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L154-0273?
Check Price and Availability of L154-0273, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L154-0273 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L154-0273
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L154-0273
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L154-0273 available by request