L207-0145 Screening compound: ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxylate

L207-0145 Screening compound: ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxylate
L207-0145 Screening compound: ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxylate alternative view

Chemical Structure Depiction of ChemDiv screening compound L207-0145
ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxylate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L207-0145

Molecular Formula

C23H22FN3O4S (C23 H22 FN3 O4 S)

Compound Name

ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxylate

IUPAC name

ethyl 5-{[(4-fluorophenyl)methyl]amino}-6-(4-hydroxy-3-methoxyphenyl)-3-methylimidazo[21-b][13]thiazole-2-carboxylate

SMILES

CCOC(c(s1)c(C)n2c1nc(-c(cc1)cc(OC)c1O)c2NCc(cc1)ccc1F)=O

InChI

InChI=1S/C23H22FN3O4S/c1-4-31-22(29)20-13(2)27-21(25-12-14-5-8-16(24)9-6-14)19(26-23(27)32-20)15-7-10-17(28)18(11-15)30-3/h5-11,25,28H,4,12H2,1-3H3

InChI Key

QZGDWONLPKIAHD-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27235922

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

455.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.163

Distribution Coefficient, logD

4.152

Water Solubility, LogSw

-3.97

Polar Surface Area

64.578

Acid Dissociation Constant (pKa)

8.99

Base Dissociation Constant (pKb)

4.54

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

21.70

L207-0145 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Hsp90-Targeted Library (11355 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Mechanism of action:
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L207-0145 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L207-0145?
Check Price and Availability of L207-0145, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L207-0145 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L207-0145
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L207-0145
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L207-0145 available by request