L218-0066 Screening compound: N~1~-(3,4-dimethylphenyl)-2-[2-(3-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetamide

L218-0066 Screening compound: N~1~-(3,4-dimethylphenyl)-2-[2-(3-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetamide
L218-0066 Screening compound: N~1~-(3,4-dimethylphenyl)-2-[2-(3-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L218-0066
N~1~-(3,4-dimethylphenyl)-2-[2-(3-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L218-0066

Molecular Formula

C27H24N4O3 (C27 H24 N4 O3)

Compound Name

N~1~-(3,4-dimethylphenyl)-2-[2-(3-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetamide

IUPAC name

N-(34-dimethylphenyl)-2-[11-(3-methoxyphenyl)-13-oxo-1810-triazatricyclo[7.4.0.0^{27}]trideca-246911-pentaen-8-yl]acetamide

SMILES

Cc(cc1)c(C)cc1NC(CN(c(cccc1)c1N12)C2=NC(c2cc(OC)ccc2)=CC1=O)=O

InChI

InChI=1S/C27H24N4O3/c1-17-11-12-20(13-18(17)2)28-25(32)16-30-23-9-4-5-10-24(23)31-26(33)15-22(29-27(30)31)19-7-6-8-21(14-19)34-3/h4-15H,16H2,1-3H3,(H,28,32)

InChI Key

NDBHXNXZKPNQGJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD18171626

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

452.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.721

Distribution Coefficient, logD

4.721

Water Solubility, LogSw

-4.48

Polar Surface Area

58.777

Acid Dissociation Constant (pKa)

12.93

Base Dissociation Constant (pKb)

1.70

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

14.80

L218-0066 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Proteases

References: we are preparing a list of scientific research reports with L218-0066 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L218-0066?
Check Price and Availability of L218-0066, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L218-0066 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L218-0066
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L218-0066
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L218-0066 available by request