L218-0368 Screening compound: methyl 2-({2-[2-(4-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetyl}amino)benzoate

L218-0368 Screening compound: methyl 2-({2-[2-(4-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetyl}amino)benzoate
L218-0368 Screening compound: methyl 2-({2-[2-(4-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetyl}amino)benzoate alternative view

Chemical Structure Depiction of ChemDiv screening compound L218-0368
methyl 2-({2-[2-(4-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetyl}amino)benzoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L218-0368

Molecular Formula

C27H22N4O5 (C27 H22 N4 O5)

Compound Name

methyl 2-({2-[2-(4-methoxyphenyl)-4-oxopyrimido[1,2-a][1,3]benzimidazol-10(4H)-yl]acetyl}amino)benzoate

IUPAC name

methyl 2-{2-[11-(4-methoxyphenyl)-13-oxo-1810-triazatricyclo[7.4.0.0^{27}]trideca-246911-pentaen-8-yl]acetamido}benzoate

SMILES

COC(c(cccc1)c1NC(CN(c(cccc1)c1N12)C2=NC(c(cc2)ccc2OC)=CC1=O)=O)=O

InChI

InChI=1S/C27H22N4O5/c1-35-18-13-11-17(12-14-18)21-15-25(33)31-23-10-6-5-9-22(23)30(27(31)29-21)16-24(32)28-20-8-4-3-7-19(20)26(34)36-2/h3-15H,16H2,1-2H3,(H,28,32)

InChI Key

KFJHSNRXGOHIPF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27236104

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

482.5

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.379

Distribution Coefficient, logD

3.368

Water Solubility, LogSw

-3.78

Polar Surface Area

79.253

Acid Dissociation Constant (pKa)

8.97

Base Dissociation Constant (pKb)

0.93

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

11.10

L218-0368 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with L218-0368 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L218-0368?
Check Price and Availability of L218-0368, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L218-0368 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L218-0368
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L218-0368
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L218-0368 available by request