L227-0397 Screening compound: 1-[2-(4-FLUOROPHENYL)-5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]-N-(3-PYRIDYLMETHYL)-4-PIPERIDINECARBOXAMIDE

L227-0397 Screening compound: 1-[2-(4-FLUOROPHENYL)-5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]-N-(3-PYRIDYLMETHYL)-4-PIPERIDINECARBOXAMIDE
L227-0397 Screening compound: 1-[2-(4-FLUOROPHENYL)-5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]-N-(3-PYRIDYLMETHYL)-4-PIPERIDINECARBOXAMIDE alternative view

Chemical Structure Depiction of ChemDiv screening compound L227-0397
1-[2-(4-FLUOROPHENYL)-5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]-N-(3-PYRIDYLMETHYL)-4-PIPERIDINECARBOXAMIDE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L227-0397

Molecular Formula

C25H25FN6O (C25 H25 FN6 O)

Compound Name

1-[2-(4-FLUOROPHENYL)-5-METHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]-N-(3-PYRIDYLMETHYL)-4-PIPERIDINECARBOXAMIDE

IUPAC name

1-[2-(4-fluorophenyl)-5-methylpyrazolo[15-a]pyrimidin-7-yl]-N-[(pyridin-3-yl)methyl]piperidine-4-carboxamide

SMILES

Cc1nc2cc(-c(cc3)ccc3F)nn2c(N(CC2)CCC2C(NCc2cnccc2)=O)c1

InChI

InChI=1S/C25H25FN6O/c1-17-13-24(32-23(29-17)14-22(30-32)19-4-6-21(26)7-5-19)31-11-8-20(9-12-31)25(33)28-16-18-3-2-10-27-15-18/h2-7,10,13-15,20H,8-9,11-12,16H2,1H3,(H,28,33)

InChI Key

FMVKWKNFXCZOPS-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27236499

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

444.51

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.232

Distribution Coefficient, logD

1.078

Water Solubility, LogSw

-2.94

Polar Surface Area

55.665

Acid Dissociation Constant (pKa)

13.36

Base Dissociation Constant (pKb)

9.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.00

L227-0397 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Indoleamine 2,3-dioxygenase 1 Focused Library (5816 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Female
  • Hemic and lymphatic
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Others

References: we are preparing a list of scientific research reports with L227-0397 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L227-0397?
Check Price and Availability of L227-0397, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L227-0397 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L227-0397
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L227-0397
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L227-0397 available by request