L227-0421 Screening compound: ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate

L227-0421 Screening compound: ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate
L227-0421 Screening compound: ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate alternative view

Chemical Structure Depiction of ChemDiv screening compound L227-0421
ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L227-0421

Molecular Formula

C27H32FN5O3 (C27 H32 FN5 O3)

Compound Name

ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate

IUPAC name

ethyl 1-{1-[2-(4-fluorophenyl)-5-methylpyrazolo[15-a]pyrimidin-7-yl]piperidine-4-carbonyl}piperidine-4-carboxylate

SMILES

CCOC(C(CC1)CCN1C(C(CC1)CCN1c1cc(C)nc2cc(-c(cc3)ccc3F)nn12)=O)=O

InChI

InChI=1S/C27H32FN5O3/c1-3-36-27(35)21-10-14-32(15-11-21)26(34)20-8-12-31(13-9-20)25-16-18(2)29-24-17-23(30-33(24)25)19-4-6-22(28)7-5-19/h4-7,16-17,20-21H,3,8-15H2,1-2H3

InChI Key

XTUVAJCYVTVLJL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27236511

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

493.58

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.286

Distribution Coefficient, logD

2.132

Water Solubility, LogSw

-4.19

Polar Surface Area

59.136

Acid Dissociation Constant (pKa)

23.23

Base Dissociation Constant (pKb)

9.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

48.10

L227-0421 in Drug Discovery

Included in Screening Libraries

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L227-0421 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L227-0421?
Check Price and Availability of L227-0421, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L227-0421 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L227-0421
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L227-0421
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L227-0421 available by request